Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans.
Diabetes. 2008 May; 57(5):1246-53
Zhang X, Yeung DC, Karpisek M, Stejskal D, ..., Chow WS, Tso AW, Lam KS, Xu A. Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A. Diabetes. 2008 May; 57(5):1246-53
This is the first study to show the potential clinical relevance of FGF21 as a biomarker for metabolic syndrome, an interesting finding but that will have to be validated with many more patients.
FGF21 is an endocrine factor (not a specific adipokine) that has been mainly studied in mice or human cell lines and is induced during...
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