Sickle cell vasoocclusion and rescue in a microfluidic device.
Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20496-500
Carlo Brugnara
24 Dec 2007
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Interesting Hypothesis, Technical Advance
The findings presented in this article provide an important new framework to understand sickle vasoocclusion as well as study potential pharmacological inhibitors of this process.
The authors validate a novel microfluidic in vitro approach to study the dynamic events underlying vasoocclusion and resolution of vasoocclusion in sickle...
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