Motif module map reveals enforcement of aging by continual NF-kappaB activity.
Genes Dev. 2007 Dec 15; 21(24):3244-57
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Genes Dev. 2007 Dec 15; 21(24):3244-57
Most microarray studies that I read do not exploit the use of promoter elements as targets to identify common pathways activated in physiological contexts as these authors have done. This approach of 'motif mapping' looks like it will be a valuable tool that combines modern molecular biology, physiology and high-powered statistics...
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