PI3K-beta plays a critical role in neutrophil activation by immune complexes.
Sci Signal. 2011; 4:ra23
Steve Ward
06 Jun 2011
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New Finding
This exciting study provides the first evidence that the beta isoform of phosphoinositide 3-kinase (PI3Kbeta) plays an essential, non-redundant role in the efficient activation of mouse neutrophils by IgG-containing immune complexes.
Neutrophils detect these immune complexes through Fc receptors for IgG (FcgammaRs). Predictab PI3Kbeta...
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