PI3K-beta plays a critical role in neutrophil activation by immune complexes.
Sci Signal. 2011; 4:ra23
Kulkarni S, Sitaru C, Jakus Z, Anderson KE, ..., Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. Sci Signal. 2011; 4:ra23
This exciting study provides the first evidence that the beta isoform of phosphoinositide 3-kinase (PI3Kbeta) plays an essential, non-redundant role in the efficient activation of mouse neutrophils by IgG-containing immune complexes.
Neutrophils detect these immune complexes through Fc receptors for IgG (FcgammaRs). Predictab PI3Kbeta...
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