Nature. 2007 Oct 25; 449(7165):1003-7
The hunt for the true gut stem cell has been long and hard. This is an important paper because it demonstrates that a single protein, Lgr5, could mark stem cells in multiple adult tissues and cancerous tissues.
These lineage-tracing experiments show Lgr5 expressing crypt base columnar cells generate all colonic epithelial lineages...
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