Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.
Cell. 2007 Jun 29; 129(7):1311-23
Rinn JL, Kertesz M, Wang JK, Squazzo SL, ..., Helms JA, Farnham PJ, Segal E, Chang HY. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY. Cell. 2007 Jun 29; 129(7):1311-23
This paper brings insight, and will add fuel, to the current debate upon whether non-coding RNAs are involved in activation or silencing of Hox genes, and whether they do so in cis or in trans.
The authors show that adult human fibroblasts from different positions along the body axis retain their different embryonic patterns of Hox...
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