Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A.
Sci Signal. 2011; 4(171):ra28
This paper suggests an interesting mechanism to explain why monophosphoryl lipid A (MLA) is a poor inducer of interleukin (IL)-1beta production and shows that MLA suppresses inflammasome assembly in response to other stimuli.
Unlike fully phosphorylated lipid A, MLA poorly stimulates IL-1beta secretion and MyD88-dependent gene...
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