Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.
J Cell Biol. 2011 May 16; 193(4):667-76
Gu Y, Forostyan T, Sabbadini R, Rosenblatt J. J Cell Biol. 2011 May 16; 193(4):667-76
This exciting paper identifies a lipid signal that apoptotic cells send to their neighbors, leading to the extrusion of dying cells from epithelial layers.
The authors found that sphingosine-1-phosphate (S1P) is produced in apoptotic cells and triggers actomyosin contraction in the surrounding epithelial cells. Blocking production...
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