Retraction of synapses and dendritic spines induced by off-target effects of RNA interference.
J Neurosci. 2006 Jul 26; 26(30):7820-5
Alvarez VA, Ridenour DA, Sabatini BL. J Neurosci. 2006 Jul 26; 26(30):7820-5
The expression of short hairpin RNA (shRNA), a widely used method to manipulate gene expression and determine gene function, can have unwanted effects through the activation of RNA-responsive mammalian cell defense mechanisms. The authors report that in hippocampal neurons expression of a subset of shRNAs directed against coding sequences...
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