Protein stability promotes evolvability.
Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5869-74
This paper by Bloom et al. provides evidence that the degree of functional change that can be introduced by mutation of a protein is constrained by the overall stability of the protein.
Put simply, proteins that are more stable can tolerate more substantial changes to their structure and function.
This simple and intuitive,...
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