The mechanism of HIV-1 core assembly: insights from three-dimensional reconstructions of authentic virions.
Structure. 2006 Jan; 14(1):15-20
Briggs JA, Grünewald K, Glass B, Förster F, Kräusslich HG, Fuller SD. Structure. 2006 Jan; 14(1):15-20
The authors have used cryo-electron tomography to visualize
HIV-1 virions in greater clarity compared to previous attempts and this allows them to suggest a mechanism of core assembly by which growth initiates at the narrow end of the cone and proceeds toward the distal end of the virion.
This mechanism limits the sizes and shapes...
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