The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Nature. 2005 Oct 20; 437(7062):1109-11
Koo SH, Flechner L, Qi L, Zhang X, ..., Boussouar F, Brindle P, Takemori H, Montminy M. Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. Nature. 2005 Oct 20; 437(7062):1109-11
I like this paper because it provocatively argues that signals which activate AMPK in liver may block gluconeogenesis by phosphorylaing TORC2, thus rendering this CREB coacivator inactive by retaining it in the cyptoplasm.
AMPK is an energy sensing kinase that helps protect cells from ATP depletion, while TORC2 is a coactivator of...
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