Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.
Genes Dev. 2004 Mar 15; 18(6):641-59
Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT. Genes Dev. 2004 Mar 15; 18(6):641-59
This study demonstrates the importance of Sonic hedgehog (Shh) palmitoylation in mouse development, by examining both a knockout of the palmitoyltransferase gene Skn and a knockin of a cys-to-ser mutation in Shh that prevents its palmitoylation.
The paper also shows that Shh lacking lipid modifications cannot form a multimeric...
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