The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.
J Biol Chem. 2006 Mar 17; 281(11):7228-36
Robert Liddington
01 Aug 2006
These findings are directly challenged in two recent papers {1,2} that show that activation of vinculin requires the cooperative action of ligands, rather than the action of one ligand alone.
References: {1} Cohen et al. J Biol Chem 2006, 281:16006-15 [PMID:16608855]; {2} Cohen et al. J Biol Chem 2005, 280:17109-17 [PMID:15728584]....
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