B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.
J Immunol. 2002 Jul 15; 169(2):865-72
Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M. J Immunol. 2002 Jul 15; 169(2):865-72
Analysis of B cell development in an Ig-alpha knockout mouse and comparison with Ig-beta and Ig-alpha/Ig-beta double deficient mice provides a very clear demonstration of the important and non-redundant role of these proteins in progression past the earliest progenitor stages.
While normal levels of V(D)J recombination are foun revising...
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