B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta.
J Immunol. 2002 Jul 15; 169(2):865-72
Richard Hardy
10 Sep 2002
|
New Finding
Analysis of B cell development in an Ig-alpha knockout mouse and comparison with Ig-beta and Ig-alpha/Ig-beta double deficient mice provides a very clear demonstration of the important and non-redundant role of these proteins in progression past the earliest progenitor stages.
While normal levels of V(D)J recombination are foun revising...
INDIVIDUAL SUBSCRIPTIONS
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.
Subscribe for $9.95/monthINSTITUTIONAL SUBSCRIPTIONS
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.
Recommend to your LibrarianIf you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.
Request an Institutional Trialyour institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.