Structural clusters of evolutionary trace residues are statistically significant and common in proteins.
J Mol Biol. 2002 Feb 8; 316(1):139-54
Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O. J Mol Biol. 2002 Feb 8; 316(1):139-54
The application of the evolutionary trace method large scale to
identify functional sites on protein 3D structures is described. The authors remove subjectivity from the original method, and show that it is able to identify known functional sites automatically.
Evolutionary trace uses phylogenetic information to predict residues...
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