A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis.
EMBO J. 2001 Dec 17; 20(24):7197-208
Calvo D, Victor M, Gay F, Sui G, ..., Wen G, Maduro M, Rothman J, Shi Y. Calvo D, Victor M, Gay F, Sui G, Luke MP, Dufourcq P, Wen G, Maduro M, Rothman J, Shi Y. EMBO J. 2001 Dec 17; 20(24):7197-208
The authors show that the C. elegans T cell factor (TCF) transcription factor repressor POP-1 prevents endoderm fate in a mesodermal precursor by repressing the transcription of a GATA factor called END-1, which is required for endoderm fate; this repression occurs through the recruitment of a Groucho related co-repressor and the...
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