Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin.
Science. 2001 Aug 24; 293(5534):1484-7
Chiosis G, Boneca IG. Science. 2001 Aug 24; 293(5534):1484-7
This work shows how vancomycin-resistant bacteria could be re-sensitized with small molecules catalyzing the selective cleavage of the mutated D-Ala-D-Lac ester bond at the depsipeptide termini of the peptidoglycan wall.
The authors used a large combinatorial library of acylated tripeptides that was incubated against a labeled...
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