Extracellular blockade of K(+) channels by TEA: results from molecular dynamics simulations of the KcsA channel.
J Gen Physiol. 2001 Aug; 118(2):207-18
Crouzy S, Bernèche S, Roux B. J Gen Physiol. 2001 Aug; 118(2):207-18
This computational study of tetraethylammonium (TEA) blockade of a K+ channel of known structure offers a novel suggestion for the underlying chemistry of the specific interaction of TEA with the outer "mouth" of a K+ channel.
Specifically, the TEA-ligating groups -- four aromatic rings symmetrically placed around the channel's...
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