Cellular Death & Stress Responses | Genomics | Cell Signaling | Liver Biology & Pathobiology
Preapoptotic cell stress response
Biochemical Society 2011 - Stress Responses - Molecules, Organisms and Environment meeting, 4 - 7 Jan 2011, STR1.32
Environmental stresses, which are too weak to induce apoptosis, may trigger changes in protein expression and signaling pathways of the affected cells. One of them is preapoptotic cell stress response, which is characterized by reversible changes in distribution of some proapoptotic proteins (e.g. caspase-9, Bax) and by a reduced ability to trigger apoptosis through the mitochondrial pathway (hepatology).
Intracellular changes in protein distribution during preapoptotic cell stress response appear similar to those at the beginning of apoptosis in the liver and in primary hepatocytes. Nevertheless, the affected cells are not apoptotic, since the changes in intracellular protein distribution are reversible, the cells have normal morphology and function and mitochondria are energized.
Apoptosis can be triggered in the presence of an additional signal and is not initiated through the activation of caspase-9. Preapoptotic cell stress response may prevent unnecessary apoptosis caused by mild stress, therefore is an adaptation to enable the survival of cells.
No relevant conflicts of interest declared.
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