Membranes & Sorting | Membrane Proteins & Energy Transduction | Structural Genomics | Experimental Biophysical Methods
The Membrane Protein Laboratory at Diamond: What we can do for you
Isabel Moraes*, So Iwata, Alex Cameron, Kostas Beis, Gwyndaf Evans, Momi Iwata, Tian Geng, Mat Jennions
*Corresponding author: Isabel Moraes
Membrane Protein Laboratory, Diamond Light Source Ltd, Oxfordshire, UK
Division of Molecular Biosciences, Imperial College, London, UK
F1000Posters 2011, 2: 101 (poster) [ENGLISH]
Poster [13.77 MB]
Biochemical Society 2011 - Annual Symposium - Recent Advances in Membrane Biochemistry, 5 - 7 Jan 2011, P120
Membrane proteins are the supreme example where more effort is needed in structural biology. In spite of their abundance and importance, of the more than 60,000 protein structures in the Protein Data Bank, only around 200 of these structures represent unique membrane proteins.
To facilitate structural studies on membrane proteins, The Membrane Protein Laboratory at Diamond Light Source Ltd (Diamond-MPL) was created. The MPL is a research and training state-of-the-art user facility open to scientists from laboratories anywhere in the world interested in solving the 3-dimensional structures of membrane proteins by X-ray crystallography.
In addition, the MPL works in close collaboration with the I24 beamline at Diamond. The I24 beamline has been designed to address the challenging problems of membrane protein and multi-protein complex structure determination where crystals are typically very small and weakly diffracting.
No relevant conflicts of interest declared.
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