Respiratory Physiology | Diabetes & Obesity | Epidemiology
Markers of lung function and inflammation in West Indian diabetics
LM Pinto Pereira*, T Seemungal, S Teelucksingh, BS Nayak
*Corresponding author: LM Pinto Pereira
Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago
F1000Posters 2010, 1: 580 (poster) [ENGLISH]
Poster [976.56 KB]
Presented at
European Respiratory Society Annual Congress 2010,
18 - 22 Sep 2010, P601
West Indian populations are known to have a high prevalence of diabetes and obesity which have accelerated following the replacement of agriculture–dependent economies by urbanization, tourism and petro-chemical based industries.
We hypothesized that diabetics (using acanthosis nigricans [AN] as a marker of insulin resistance) have poor lung function (FEV1, FVC) and inflammatory responses (hs–CRP, skin vasoconstrictor response [SVC]).
Correlates (R,P) were strong for AN with poor SVC (-0.515, <0.001) and negatively correlated with residual FVC (-0.19, 0.048). Residual FEV1 was negatively correlated with diastolic BP (-0.219, 0.023) and hs-CRP (-0.234, 0.015) and, finally, residual FVC was negatively correlated with systolic BP (-0.208, 0.031), diastolic BP (-0.247, 0.01), serum uric acid (-0.20, 0.038), and weight (-0.25, 0.038).
Lung function is not optimal in West Indian diabetics and is negatively correlated with age, BMI, waist circumference, long standing dyslipidaemia, hs-CRP and acanthosis nigricans.
No relevant conflicts of interest declared.
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