Genomics | Evolutionary Ecology
Does an introgressed domesticated MHC-allele contribute to overdominance in Alpine ibex?
Simon Aeschbacher*, Lukas F Keller, Nick H Barton
*Corresponding author: Simon Aeschbacher
University of Edinburgh, , UK
Institute of Science and Technology Austria, , Austria
F1000Posters 2010, 1: 282 (poster) [ENGLISH]
Poster [1.09 MB]
Society for Molecular Biology and Evolution 2010 meeting, 4 - 8 Jul 2010, P-S01-01
One of the two alleles present at exon 2 of the DRB MHC class II gene in Alpine ibex has most likely introgressed via hybridisation from domestic goat at least 100 years ago. These days, the frequency of the ‘goat’ allele ranges up to 0.3 in several demes in the Swiss Alps.
We therefore asked whether these high frequencies are a consequence of selection favouring the goat allele. For a small subset of six demes we jointly estimated the strength of selection and the migration rate between demes.
Surprisingly, we found evidence for weak selection disfavouring the goat allele. However, this result may be a consequence of the rather conservative way we inferred the initial frequency of the ‘goat’ allele in the first place.
In the future, we aim to better account for the confounding role of the initial frequency and we will include eight more demes in the analysis.
No relevant conflicts of interest declared.
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