Bioinformatics | Evolutionary/Comparative Genetics | Pharmacogenomics
Co-evolutionary dynamics of relaxin family peptides and their receptors in deuterostomes
Society for Molecular Biology and Evolution 2010 meeting, 4 - 8 Jul 2010, P-S13-40
We undertook a bioinformatic analysis of the relaxin family peptides and their receptors in deuterostomes with a main focus on teleosts fish and humans.
We hypothesize that gene duplication and loss, chromosomal fission and fusion have contributed to the diversification of the relaxin family in distinct deuterostome lineages.
We conclude that differences in the number of ligand and receptor genes and their linkage relationships, in particular in mammalian and teleost lineages, suggest considerable variation in ligand-receptor interaction and their physiological functions.
Currently, we are performing additional bioinformatic and experimental analyses to confirm the proposed co-evolutionary relationships of the relaxin peptide family and their receptors.
No relevant conflicts of interest declared.
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