Microbial Evolution & Genomics | Microbial Growth & Development
The evolution of stress-induced hypermutation
Yoav Ram*, Lilach Hadany
*Corresponding author: Yoav Ram
Department of Molecular Biology and Ecology of Plants, Life Science Faculty, Tel-Aviv University, Tel-Aviv, Israel
F1000Posters 2011, 2: 1484 (poster) [ENGLISH]
Poster [1.42 MB] | Resulting articles
Presented at
13th Congress of the European Society for Evolutionary Biology 2011,
20 - 25 Aug 2011, B5-Sy24-i006-R
Empirical studies show that various stresses induce hypermutation in bacteria, but theoretical treatment of this phenomenon is lacking. We used deterministic and stochastic models to study the evolution of stress-induced hypermutation in infinite and finite size populations of bacteria.
Our results show that stress-induced hypermutation is advantageous for bacteria at both the individual and the population levels and that it is likely to evolve in populations of bacteria in a wide range of conditions because it is favored by selection.
Our results imply that mutations are not, as the current view holds, uniformly distributed in populations, but rather that mutations are more common in stressed individuals and populations.
No relevant conflicts of interest declared.
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