Renal, Fluid & Electrolyte Physiology | Endocrinology | Hemodynamics, Vascular Biology & Hypertension Secondary to Kidney Disease | Mineral Metabolism & the Kidney | Pathophysiology of Chronic Kidney Disease (CKD) | Bone & Mineral Metabolism | Methods for Diagnostic & Therapeutic Studies
Effects of parathyroidectomy on endothelial progenitor cells
Carlo Lomonte*, Clorinda Derosa, Pasquale Libutti, Annalisa Teutonico, Domenico Chimienti, Maurizio Antonelli, Andrea Bruno, Savino Cocola, Carlo Basile
*Corresponding author: Carlo Lomonte
Nephrology and Dialysis Unit, Miulli General Hospital, Acquaviva delle Fonti, Italy
F1000Posters 2011, 2: 1210 (poster) [ENGLISH]
Poster [1.14 MB]
48th Congress of the European Renal Association and European Dialysis and Transplant Association 2011, 23 - 26 Jun 2011, F-456
Circulating endothelial progenitor cells (EPCs) are a heterogeneous cell population with different phenotypes that play a key role in the maintenance of endothelial homeostasis and in the enhancement of the vascular repair. Uremia hinders EPCs differentiation and reduces their mobilization from the bone marrow. Parathyroid hormone (PTH) is an active stimulator of bone marrow osteoblasts and is involved in the niche organization, the microenvironment which controls the turnover and fate of EPCs. However, the role of PTH on the levels of circulating EPCs is not fully understood.
The aim of this study was to evaluate the behaviour of the EPCs in a group of uremic patients undergoing parathyroidectomy (PTx).
Even though there are no unifying phenotyping markers in the detection of EPCs, our data show that phenotype CD34+/KDR+/CD45dim, identifying a early EPC, is reduced in hemodialysis patients having high levels of serum PTH and that the PTx may increase the number of this circulating cells population.
No relevant conflicts of interest declared.
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