Cellular Death & Stress Responses | Immunopharmacology & Hematologic Pharmacology | Toxicology | Renal Pharmacology
The protective effect of erdosteine on cyclosporine induced chronic nephrotoxicity in rats
Ebru Uz, Burak Uz, Arif Kaya, Derya Akdeniz*, Nuket Bavbek Ruzgaresen, Efkan Uz, Faruk Hilmi Turgut, Reyhan Bayrak, Ayse Carlioglu, Ali Akcay
*Corresponding author: Derya Akdeniz
Faculty of Medicine, Fatih University, Büyükçekmece, Istanbul, Turkey
F1000Posters 2011, 2: 1178 (poster) [ENGLISH]
Poster [308.37 KB]
48th Congress of the European Renal Association and European Dialysis and Transplant Association 2011, 23 - 26 Jun 2011, Sa-246
The aim of this study was to determine the protective effect of erdosteine on Cyclosporine (CsA) induced chronic nephrotoxicity.
We assessed oxidative stress enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), malondialdehyde (MDA) and nitric oxide (NO) levels) and light microscopic changes before and after erdosteine treatment in damaged kidneys. The rats were assigned randomly to one of four groups, these were: control group (n=8), CsA group (15 mg/kg day, n=8), erdosteine treated group (10 mg/kg day orally, n=8) and CsA+ erdosteine group (n=8). CsA nephrotoxicity was induced by administrating oral dose of 15 mg/kg CsA daily for 21 days.
For the first time, we have demonstrated in vivo that erdosteine causes improvement in CsA related nephrotoxicity by increasing GSHPx, CAT, MDA and NO levels. Histological clues of renal damage can be diminished by erdostein treatment. As an exogenous antioxidant agent, erdosteine may return CsA nephrotoxicity by reducing its effect on lipid peroxidation and glomerular ROS production.
No relevant conflicts of interest declared.
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