Neurobiology of Disease & Regeneration | Substance Abuse | Liver Failure & Liver Disease
Relationship between liver function and brain shrinkage in patients with alcohol dependence
Chun-Hsin Chen, Jonathan Walker, Reza Momenan, Robert Rawlings, Markus Heilig, Daniel W Hommer*
*Corresponding author: Daniel W Hommer
Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
F1000Posters 2011, 2: 1037 (poster) [ENGLISH]
66th Society of Biological Psychiatry Annual Meeting 2011, 11 - 13 May 2011, 893
Oxidative stress is one of the mechanisms to explain alcohol-induced brain shrinkage and also one of the causes of alcohol-induced hepatotoxicity.
The aim of this study was to assess the correlation between liver function and brain morphological indexes in patients with alcohol dependence.
We found that liver function impairments were correlated with brain volume shrinkage in patients with alcohol dependence. Especially, the correlation between gamma-glutamyl transpeptidase and brain shrinkage outweighed aging effect in female patients. The mechanisms underlying the relationship between liver function and brain need to be studied in the future.
No relevant conflicts of interest declared.
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