Mood Disorders | Diabetes & Obesity | Child & Adolescent Psychiatry
Obesity and the longitudinal course of pediatric bipolar disorder
Benjamin I Goldstein*, David Axelson, Tina R Goldstein, Michael Strober, Neal D Ryan, Martin B Keller, Boris Birmaher
*Corresponding author: Benjamin I Goldstein
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
F1000Posters 2011, 2: 672 (poster) [ENGLISH]
Poster [779.92 KB]
66th Society of Biological Psychiatry Annual Meeting 2011, 11 - 13 May 2011, 968
To examine the association between obesity and the course of pediatric bipolar disorder (BP).
Subjects (N=323), 7-17 years old, were in the Course and Outcome of Bipolar Illness among Youth (COBY) study. Illness characteristics during 4 years of follow-up were examined as they relate to obesity at intake.
Compared to non-obese subjects, obese subjects spent a significantly greater proportion of follow-up weeks with syndromal symptoms, which was mainly accounted for by major depressive episodes. Obese subjects were significantly more likely to experience syndromal manic and depressive episodes. Obese subjects were more likely to demonstrate psychosis during follow-up, and there was a trend toward increased rates of psychiatric hospitalization.
Obesity is associated with a more severe prospective longitudinal course of BP among youth.
This study was funded by NIMH grant 2 R01 MH59929 (B. Birmaher, PI). Corresponding author Benjamin Goldstein received grant support from Pfizer and is a speaker honoraria for Purdue Pharma.
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