Gastrointestinal Pharmacology | Molecular Pharmacology | Methods for Diagnostic & Therapeutic Studies | Esophagus
Effect of melatonin in functional heart burn – a randomized placebo-controlled clinical trial
Patrick Basu*, Niraj Shah, Nithya Krishnaswamy, Chris Tang
*Corresponding author: Patrick Basu
Columbia University New York, New York, NY, USA
North Shore University Hospital at Forest Hills, New York, NY, USA
F1000Posters 2011, 2: 656 (slide presentation) [ENGLISH]
Slide Presentation [1.57 MB] | Recommended by F1000Prime
Presented at
Digestive Disease Week 2011,
7 - 10 May 2011, 1032
This study evaluates the possible role of melatonin in Functional Heart Burn (FHB) as currently there is no evidenced based modality of therapy for FHB.
Melatonin has been implicated in acid suppression, anti-ulcer, sleep (by modulating the intrinsic circadian rhythm), immune modulation, tissue healing and repair and the overall altering of dysmotility in the bowel. Melatonin is abundant in the GI tract, is a natural product with minimal side events and is non-teratogenic, so it can be used safely in pregnancy. There are no major problems for metabolic degradation or excretion because it bypasses CPT 450 pathways unlike Tricyclic, SSRI, SNRI, Baclofen and 5Ht components.
This study shows that Melatonin is effective, efficacious and provides relatively low side events with significant amelioration of functional heart burn and GERD-HQRL score. It is very inexpensive and within a comfort zone can be used for long durations. A larger trial will be conducted to validate the study’s findings.
No relevant conflicts of interest declared.
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