Reproductive Physiology | Endocrinology | Menstrual Abnormalities & Abnormal Uterine Bleeding | Psychological Challenges & Issues for Women | Mood Disorders | Neuro-Endocrinology & Pituitary | Reproductive Endocrinology & Infertility
Association between BDNF and estrogen levels in women with bipolar disorder
MF Sulzbach-Vianna*, E Brietzke, JF Tramontina, F Migliavacca, PD Goi, BW Aguiar, GD Colpo, KM Ceresér, M Kauer-Sant'Anna, F Kapczinski
*Corresponding author: MF Sulzbach-Vianna
Bipolar Disorder Program, and Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
INCT for Translational Medicine, Programa de Pós-Graduação em Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
F1000Posters 2011, 2: 638 (poster) [ENGLISH]
Poster [355.86 KB]
Presented at
66th Society of Biological Psychiatry Annual Meeting 2011,
11 - 13 May 2011, 1023
The study aims to investigate the relationship between brain-derived neurotrophic factor (BDNF) levels and hormones involved in hypothalamus-pituitary-gonadal axis in women with bipolar disorder (BD), during reproductive years and also in a postmenopausal group. In addition, differences across the two phases of menstrual cycle were also evaluated in the group during reproductive years.
- There was a statistically significant positive correlation between BDNF and estrogen (E) levels, with higher BDNF levels being associated with estrogenic stimulation.
- Our findings are in line with a body of evidence that postulated that estrogen has an important neuromodulatory action.
- A neuroprotective effect of estrogen was consistently demonstrated in rats, with this hormone being responsible for simulating myelinisation. The exact mechanism through which E exerts its neuroprotective effect is unknown but some studies suggest the existence of a cross-talk between these mediators.
Funding/Competing Interests: No relevant conflicts of interest declared.
No relevant competing interests disclosed.
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