Innate Immunity | Immunity to Infections | Allergy & Hypersensitivity | Bacterial Infections | Atopic Dermatitis & Other Forms of Eczema | Skin Infections (incl. STDs)
Interleukin-18 level is elevated in the horny layer in atopic dermatitis patients and associated with Staphylococcus aureus colonisation in patients with relatively low IgE production
Yusuke Inoue, Michiko Aihara, Ikuyo Harada, Junko Komori, Mio Kirino, Yoji Nagashima, Zenro Ikezawa*
*Corresponding author: Zenro Ikezawa
Department of Environmental Immuno-Dermatology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
F1000Posters 2011, 2: 639 (slide presentation) [ENGLISH]
22nd World Congress of Dermatology 2011, 24 - 29 May 2011, P0269
Atopic dermatitis (AD) may show high, mild or low IgE production. Epidermal cell interleukin (IL)-18 production induced by Staphylococcus aureus protein A causes severe dermatitis, and serum IgE levels are gradually elevated later in AD model mice. The mechanism behind this dermatitis is independent of Th2 or IgE responses and is thus a model of low or mild IgE production AD.
colonisation may contribute to epidermal IL-18 production, especially in the AD group with relatively low IgE production.
This is the first report on the quantification of epidermal IL-18 production in patients with AD. Measurement of IL-18 in the horny layer is useful for evaluating the IL-18 production of epidermal keratinocytes as well as the effects of therapies in patients with AD.
No relevant conflicts of interest declared.
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