Behavioral Neuroscience | Medical Genetics | Animal Genetics | Cognitive Neuroscience | Neurobiology of Disease & Regeneration | Schizophrenia & Other Psychoses
A “double hit” of post-weaning social isolation and NMDAR1 heterozygous knockdown results in a mouse model of schizophrenia
R Shin*, JH Kogan, K Tajinda, N Walton, C Heusner, Q Chen, S Miyake, K Tamura, M Matsumoto
*Corresponding author: R Shin
CNS, Astellas Research Institute of America LLC, Skokie, IL, USA
F1000Posters 2011, 2: 572 (poster) [ENGLISH]
Poster [1.49 MB]
Presented at
66th Society of Biological Psychiatry Annual Meeting 2011,
11 - 13 May 2011, 734
The purpose of the study was to evaluate gene and environment interaction in a potential model of schizophrenia by employing a mouse line that maintains a 30% knockdown of the NMDAR1 subunit coupled with social isolation at weaning.
The hypothesis is that the genetic and environmental factors when influenced alone will produce subtle deficits, but when acting synergistically, it will likely elicit robust behavioral abnormalities as seen in human patients.
Our results show that a reduction in NMDAR1 and social isolation leads to working and long term memory impairments, social isolation, and hyperactivity. These features characterize the positive, negative and cognitive domains in schizophrenia. We also report changes in gene expression relating to neurogenesis, suggesting a dysregulation of the adult neuronal cell cycle.
We currently will investigate neuronal proliferation and survival using BrdU labeling, and perform microarray studies to elucidate key genes that are altered in this model.
No relevant conflicts of interest declared.
Please note that most posters on this site present work that is preliminary in nature and has not been peer reviewed.
This poster is open access subject to the CC BY-NC Creative Commons 3.0 License
