Theoretical & Computational Neuroscience | Morphogenesis & Cell Biology | Neurodevelopment | Neuronal & Glial Cell Biology
Mechanical tension is instrumental in neuronal and network development
A Ayali*, Y Hanein, S Anava, O Tadmor
*Corresponding author: A Ayali
Department of Zoology, Tel-Aviv University, Tel-Aviv, Israel
F1000Posters 2011, 2: 429 (poster) [ENGLISH]
Poster [4.00 MB]
Presented at
Wiring the Brain: Making Connections meeting 2011,
12 - 15 Apr 2011, P2.1
A complete understanding of the complex development of the brain will be achieved only by taking into account the effects of physical-mechanical forces.
In this study we investigated the functional role of mechanical tension in neuronal migration during network development.
We used a well established culture preparation of invertebrate neurons and recently developed nanotechnology, together with mathematical analysis and computer simulations.
Based on our results we suggest a model of tension-induced neuronal migration which is instrumental in shaping the morphology of the neurons and the network.
No relevant conflicts of interest declared.
Please note that most posters on this site present work that is preliminary in nature and has not been peer reviewed.
This poster is open access subject to the CC BY-NC Creative Commons 3.0 License
