Theoretical & Computational Neuroscience | Morphogenesis & Cell Biology | Neurodevelopment | Neuronal & Glial Cell Biology
Mechanical tension is instrumental in neuronal and network development
A Ayali*, Y Hanein, S Anava, O Tadmor
*Corresponding author: A Ayali
Department of Zoology, Tel-Aviv University, Tel-Aviv, Israel
F1000Posters 2011, 2: 429 (poster) [ENGLISH]
Poster [4.00 MB]
Wiring the Brain: Making Connections meeting 2011, 12 - 15 Apr 2011, P2.1
A complete understanding of the complex development of the brain will be achieved only by taking into account the effects of physical-mechanical forces.
In this study we investigated the functional role of mechanical tension in neuronal migration during network development.
We used a well established culture preparation of invertebrate neurons and recently developed nanotechnology, together with mathematical analysis and computer simulations.
Based on our results we suggest a model of tension-induced neuronal migration which is instrumental in shaping the morphology of the neurons and the network.
No relevant conflicts of interest declared.
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