Pediatric Problems in Critical Care | Congenital Heart Disease | Acute Cardiovascular Problems | Neurological Problems in Critical Care | Pediatric Anesthesiology | Perioperative Critical Care | Cardiovascular Medicine in Anesthesia: Clinical Science
Cerebral autoregulation in peri-operative Glenn patients
Valerie Y Chock*, Archana Verma, Gail E Wright, V Mohan Reddy, Chandra Ramamoorthy
*Corresponding author: Valerie Y Chock
Department of Pediatrics, Department of Anesthesia and Department of Pediatric Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA, USA
F1000Posters 2011, 2: 353 (poster) [ENGLISH]
Poster [997.47 KB] | Recommended by F1000Prime
Presented at
SPA/AAP Pediatric Anesthesiology 2011,
31 Mar - 3 Apr 2011, 21
Infants with congenital heart disease with functional single ventricle physiology are at high risk of neurodevelopmental impairment, and potential disruption of cerebral autoregulation in the peri-operative period may contribute to neurologic injury.
We hypothesized that infants undergoing a bidirectional Glenn procedure will have periods of cerebral pressure passivity that resolve within 48 hours of surgery.
During a bidirectional Glenn procedure, infants are at significant risk for disrupted cerebral autoregulation with maximal cerebral pressure passivity occurring intra-operatively and slow recovery of cerebral autoregulation over a 48 hour post-operative period. Strategies to improve cerebral oxygenation during this time period should therefore be implemented. The project is currently enrolling additional subjects.
No relevant conflicts of interest declared.
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