Integrative Physiology | Metabolic Disorders in Critical Care
Relation between hypernatremia and non-inflammatory hyperthermia in critically ill patients
A Oude Lansink*, QAD Kroon, MW Nijsten
*Corresponding author: A Oude Lansink
Intensive Care Adults, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 96 (poster) [English]
Poster [360.21 KB]
NVIC Nederlandse Intensivistendagen (Dutch Society of Intensive Care Meeting) 2013, 13 - 15 Feb 2013, P000
University Medical Center Groningen (UMCG)
Hypernatremia is a frequent complication in patients who have a prolonged ICU stay. Elevated sodium levels may interfere with perspiration and thus with thermoregulation. We hypothesized that hypernatremia may lead to hyperthermia in ICU patients, independent of systemic inflammation.
A comparatively straightforward regression model showed a satisfactory predictive power for body temperature. Moreover, we observed that sodium levels were independently related to body temperature. When patients develop fever under hypernatriema with low levels of inflammatory markers such as CRP, hypernatremia itself should be considered as a direct cause.
The mechanisms underlying this potential association deserve further study.
No relevant competing interests disclosed.
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