Technology & Monitoring in Anesthesiology | General Pharmacology
Effect of atropine, norepinephrine and phenylephrine on cerebral oxygenation and cardiac output during anesthesia
AF Kalmar*, Marieke Poterman, Eline A Mooyaart, Jaap Jan Vos, Michel MRF Struys, Thomas WL Scheeren
*Corresponding author: AF Kalmar
Anaesthesiology, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 78 (poster) [English]
Poster [678.75 KB]
Anesthesiology 2012, 13 - 17 Oct 2012, A840
University Medical Center Groningen (UMCG)
Induction of general anesthesia often induces unwanted hypotension which is commonly treated with vasoactive medication to restore an appropriate blood pressure. Phenylephrine, norepinephrine and atropine are commonly used agents for this purpose with different pharmacological effects.
Both phenylephrine and norepinephrine increased MAP sufficiently, while phenylephrine tended to decreased CO and SctO 2 , probably due to its predominant alpha-adrenergic action. Norepinephrine preserved CO, but still moderately decreased SctO 2 . With regard to the desired maintenance of (cerebral) organ perfusion, atropine shows the most beneficial effect with a prominent combined increase in MAP, CO and SctO 2 .
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