Cardiovascular Physiology / Circulation | Neural Homeostasis | Coronary Artery Disease | Neurological Problems in Critical Care | Neurosurgical Care | Cardiovascular Medicine in Anesthesia: Basic Science
Intraoperative cerebral tissue oxygenation and postoperative cognitive dysfunction after on- and off-pump coronary artery bypass surgery
AE van Harten, WF Kok, TWL Scheeren, AR Absalom*
*Corresponding author: AR Absalom
Anaesthesiology, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 70 (poster) [English]
Poster [471.66 KB]
Anesthesiology 2012, 13 - 17 Oct 2012, P000
University Medical Center Groningen (UMCG)
The incidence of postoperative cognitive dysfunction (POCD) after cardiac surgery is up to 65% at hospital discharge (1). For a long time it was assumed that POCD is caused by impaired cerebral tissue oxygenation (cSO2) due to the physiological alterations associated with cardiopulmonary bypass (CPB).
This randomized trial showed no difference in the incidence of intraoperative cerebral desaturation and early POCD between patients undergoing on-pump and off-pump CABG. At 3 months postoperatively, the incidence of POCD had declined significantly more in off-pump compared to on-pump patients.
Factors such as inflammatory responses to stress, anesthesia and surgery should be considered.
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