Pharmacokinetics & Drug Delivery | Neuroimaging | Anesthetic Mechanisms | General Pharmacology
Modelling the effects of ketamine on the electroencephalogram
David TJ Liley, Hugo EM Vereecke*, Michel MRF Struys
*Corresponding author: Hugo EM Vereecke
Anaesthesiology, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 69 (poster) [English]
Poster [1.89 MB]
Anesthesiology 2012, 13 - 17 Oct 2012, A547
University Medical Center Groningen (UMCG)
Ketamine’s principle mode of action is thought to be through noncompetitive antagonism of the NMDA receptor (NMDAR) activity. However, the full scope of ketamine action is unlikely to be accounted for by the attenuation of NMDAR activity as MK801, a more potent inhibitor of NMDAR activity, induces minimal hypnosis.
Modeled differential/synergistic effects of propofol and ketamine on the resting membrane hyperpolarisation in cortical neurons may explain qualitative differences in EEG effects of ketamine alone and in the presence of propofol.
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