Cell Signaling | Stem Cells & Regeneration
The role of histone deacetylase inhibitors in hematopoietic stem cell expansion
Ronald van Os*, Marta Walasek, Sandra Olthof, Bertien Dethmers-Ausema, Martha Ritsema, Gerwin Huls, Gerald de Haan
*Corresponding author: Ronald van Os
Cell Biology, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 28 (poster) [English]
Poster [895.29 KB]
16th Congress of the European Hematology Association 2011, 9 - 12 Jun 2011, P000
University Medical Center Groningen (UMCG)
To investigate the potential of histone deacetylase inhibitors (HDIs) in prevention of stem cell differentiation and in stem cell expansion protocols.
Histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) can prevent stem cell differentiation and enhance stem cell expansion and thus may be useful in stem cell expansion protocols.
No relevant competing interests disclosed.
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