Heart Failure | Acute Cardiovascular Problems
Changes in galectin-3 levels over time predict mortality and morbidity in heart failure
Rudolf A de Boer*, Dirk J Van Veldhuisen, Lars Gullestad, Thor Ueland, Pal Aukrust, Yu Guo, Aram S Adourian, Pieter Muntendam
*Corresponding author: Rudolf A de Boer
Thoraxcenter - ECC & Experimental Cardiology Research, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2013, 4: 24 (poster) [English]
Poster [569.92 KB]
15th Annual Scientific Meeting of the Heart Failure Society of America 2011, 18 - 21 Sep 2011, P000
University Medical Center Groningen (UMCG)
Elevated circulating levels of galectin-3, a protein implicated in myocardial fibrosis and remodeling, are associated with a significantly increased risk of mortality and morbidity among heart failure (HF) patients. We examined whether changes in galectin-3 over time are associated with corresponding changes in mortality and morbidity in two chronic HF studies.
Evaluation of changes in galectin-3 levels over time provides significant predictive value in identifying HF patients at elevated risk for subsequent heart failure morbidity and mortality.
No relevant competing interests disclosed.
BG Medicine, Inc. (Waltham, MA, USA), 0000
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