Protein Chemistry & Proteomics | Bioinformatics | Biomacromolecule-Ligand Interactions | Drug Discovery & Design
Can chemical-protein interaction profiles explain side and therapeutic effects?
International Conference on Intelligent Systems for Molecular Biology (ISMB) 2012, 14 - 16 Jul 2012, P000
Chemical-protein interactome is a computational methodology with a focus on characterizing differential drug efficacy and side effects through the combined analysis of genetic polymorphisms and their impact on chemical-protein interactions and gene expression perturbations. The methodology opens up opportunities for developing patient-specific medication in terms of decreasing adverse drug reactions and revealing new uses for old drugs.
Docking-based chemical-protein interaction profile can be used to explain side effects and therapeutic effects.
Copyrights: Figure 1 was reproduced with kind permission from: Luo H, Chen J et al (2011) Nucleic Acids Res. 39(Web Server issue); W492-8.
Copyrights: Figures 1-5 were reproduced with kind permission from: Yang L, Wang K et al (2011) PLoS Comput Biol. Mar 7(3); e1002016.
The presenter is a paid employee of GlaxoSmithKline(GSK). However, the work presented was done before his tenure at GSK.
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