Cognitive Neuroscience | Neuroimaging
Increased amygdala functional connectivity during working memory among patients with mild cognitive impairment
Lucas S Broster*, Sarah Wing, Ruolei Gu, Chunyan Guo, Jessica Clark, McKinley Heflin, Gregory Jicha, Yang Jiang
*Corresponding author: Lucas S Broster
Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY, USA
Clinical and Translational Science Doctoral Program, University of Kentucky College of Medicine, Lexington, KY, USA
F1000Posters 2012, 3: 904 (poster) [English]
Poster [2.28 MB]
Presented at
18th Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2012,
10 - 14 Jun 2012, 7MT
Patients with amnestic mild cognitive impairment (aMCI) recruit additional cognitive networks to facilitate cognition, and affective network interplay has been proposed. We assessed affective network changes during a non-emotional working memory task.
Amnestic MCI was associated with inverted right amygdala working memory deactivation and uniform left amygdala deactivation. Left amygdala functional connectivity to working memory and executive function brain regions was dramatically increased.
We will next determine conditions that enhance or perturb the identified affective network recruitment to facilitate this compensation strategy.
No relevant competing interests disclosed.
Department of Energy, DE-AC05-OR22725
National Institutes of Health (NIH), AG00986
National Institutes of Health (NIH), P50AG05144-21
National Institutes of Health (NIH), 5 T32 AG 242-18
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