Microbial Evolution & Genomics | Bioinformatics | Virology
VirmugenDB: a database and analysis system of virulence factors whose mutants can be used as live attenuated vaccines
Rebecca Racz*, Monica Chung, Zuoshuang Xiang, Yongqun He
*Corresponding author: Rebecca Racz
Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
F1000Posters 2012, 3: 886 (poster) [English]
Poster [2.11 MB]
Great Lakes Bioinformatics (GLBIO) Conference 2012, 15 - 17 May 2012, A15
Live attenuated vaccines are one type of vaccine which contain a live pathogen that has a mutation in one or more genes. To better understand the mechanisms of the “virmugens” coined by us (i.e. the genes which could be mutated for development of live attenuated vaccines), we generated VirmugenDB, a novel and useful database and analysis program with an aim to collect, annotate, and analyze experimentally verified virmugens. VirmugenDB is becoming a central and vital source of virmugens and supports research in the areas of vaccinology, microbiology, and immunology.
Based on preliminary analysis, certain genes are mutated in several different pathogens to produce effective live attenuated vaccines, and therefore are interesting targets for vaccine design.
Further analysis is currently being conducted on the relationships between various live attenuated vaccines containing mutated virmugens and host gene responses to these vaccines.
No relevant competing interests disclosed.
National Institutes of Health (NIH), 1R01AI081062
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