Endocrine & Metabolic Pharmacology | Preventive Medicine | Social & Behavioral Determinants of Health | Diabetes & Obesity
Maternal taurine supplementation modifies growth and metabolism in male rat offspring of mothers fed an obesogenic diet during pregnancy and lactation
Minglan Li, Deborah Sloboda, Kendall Hepple, Mark H Vickers*
*Corresponding author: Mark H Vickers
Liggins Institute and The National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
F1000Posters 2012, 3: 837 (poster) [English]
Poster [1.08 MB]
New York Academy of Sciences 2012 - Fetal Programming and Environmental Exposures: Implications for Prenatal Care and Pre-Term Birth, 11 - 12 Jun 2012, P000
Maternal obesity results in obese offspring with metabolic and reproductive dysfunction. Taurine ameliorates adverse metabolic outcomes in offspring of protein-malnourished mothers and improves insulin sensitivity in diet-induced obesity. We hypothesised that supplementing a maternal obesogenic diet with taurine will reverse metabolic compromise in male offspring.
Taurine supplementation reduced maternal weight gain in late pregnancy and prevented elevations in TNF-alpha, glutamate and leptin but not HcY or insulin in obese dams. Taurine modified metabolic dysfunction in the offspring of obese mothers in the presence of a postnatal obesogenic diet.
No relevant competing interests disclosed.
National Research Centre for Growth and Development, 3607214
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