Cell Signaling | Leukocyte Signaling & Gene Expression | Respiratory Physiology | Airway/Respiratory Physiology
Caveolin-1, cavins and CD38-mediated Ca 2+ regulation in airway inflammation
Venkatachalem Sathish, Michael A Thompson, Gary C Sieck, Y S Prakash, Christina M Pabelick*
*Corresponding author: Christina M Pabelick
Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
F1000Posters 2012, 3: 617 (poster) [English]
International Conference of American Thoracic Society (ATS) 2012 , 17 - 22 May 2012, B86
Caveolae and CD38 play an important role in TNF-alpha-induced airway inflammation. We hypothesized that the effects of TNF-alpha on CD38 expression and function in human airway smooth muscle (ASM) involve caveolin-1.
CD38 is expressed within caveolae and upregulated by TNF-alpha. CD38 function is linked to caveolin-1 expression as well as regulatory cavin proteins that aid interaction of caveolae with intracellular structures.
To determine how the link between caveolae and CD38 contributes to airway hyperresponsiveness.
No relevant competing interests disclosed.
National Institutes of Health (NIH), HL090595
National Institutes of Health (NIH), HL074309
National Institutes of Health (NIH), HL088029
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