Renal, Fluid & Electrolyte Physiology | Renal Function & Transport Physiology
Transcutaneous measurement of renal function in conscious mice
Andrea Schreiber, Yury Shulhevich , Stefania Geraci, Juergen Hesser, Dzmitry Stsepankou, Sabine Neudecker, Stefan Koenig, Ralf Heinrich, Friederike Hoecklin, Johannes Pill, Jochen Friedemann, Frank Schweda, Norbert Gretz, Daniel Schock-Kusch*
*Corresponding author: Daniel Schock-Kusch
Institute for Medical Technology, University Heidelberg, Mannheim, Germany
F1000Posters 2012, 3: 773 (poster) [English]
49th Congress of the European Renal Association and European Dialysis and Transplant Association 2012, 24 - 27 May 2012, FP093
Here we describe a method permitting the transcutaneous measurement of glomerular filtration rate (GFR) in conscious mice independent of blood or urine samples. This approach is an extension of our previously published method used in rats (1).
Here, we present a new technique allowing the determination of renal function in freely moving mice without blood or urine sampling as well as without laboratory assays. The technique is validated against a classical plasma clearance method in healthy, UNX and pcy mice.
The corresponding author Daniel Schock-Kusch is a co-founder of Mannheim Pharma and Diagnostics GmbH, and a vendor of FITC-Sinistrin and devices for transcutaneous GFR measurement.
European Union, IST-0248048 PLACEit
European Union, NephroTools FP7 Initial Training Network (ITN)
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