Preferential susceptibility and propagation of spreading depression in superficial cortical layers

Volodymyr B Bogdanov*, Tanye Y Tang, Sylvie Multon, Sergey A Mamilov, Anatolij G Misyura, Jean Schoenen, Yuongo S Ju, KC Brennan

*Corresponding author: Volodymyr B Bogdanov
Department of Neurology, University of Utah, Salt Lake City, UT, USA

F1000Posters 2012, 3: 663 (poster) [English]

Poster [1.01 MB]

Presented at
54th American Headache Society Annual Meeting 2012, 21 - 24 Jun 2012, P70

Background / Purpose:

We expected that cortical spreading depression (CSD) susceptibility might vary by cortical depth.

Main conclusion:

We conclude that CSD has a susceptibility and tropism for superficial cortical layers, both in vitro and in vivo.

Next steps:

Induction of CSD with minimal necessary conditions for a more naturalistic model of migraine aura.

Disclosures:
No relevant competing interests disclosed.

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