Dialysis & Renal Transplantation | Hemodynamics, Vascular Biology & Hypertension Secondary to Kidney Disease | Hereditary, Genetic & Developmental Aspects of Nephrology
Polymorphisms of angiotensin converting enzyme and matrix metalloproteinase 3 genes in hemodialysis patients: association with cardiovascular morbidity and mortality
Jelena Tosic*, Zivka Djuric, Jovan Popovic, Ivana Buzadzic, Ivana Pejin-Grubisa, Nada Barjaktarevic, Nada Dimkovic
*Corresponding author: Jelena Tosic
Clinical Department for Renal Diseases, University Hospital Zvezdara, Beograd, Serbia
F1000Posters 2012, 3: 767 (poster) [English]
Poster [5.12 MB]
49th Congress of the European Renal Association and European Dialysis and Transplant Association 2012, 24 - 27 May 2012, F490
Cardiovascular morbidity is the major cause of death in hemodialysis patients. Such a high prevalence of cardiovascular deaths could have not been explained by traditional risk factors, that is why genetic susceptibility may be of importance including the renin-angiotensin system (RAS) and matrix metalloproteinase 3 (MMP3) polymorphism.
The angiotensin converting enzyme (ACE) gene polymorphism is associated with development of cerebrovascular accidents and hyperlipoproteinaemia.The results of this study have shown correlation between the 5A allele of the MMP3 gene and significantly higher risk for developing myocardial infarction, cerebrovascular accident and peripheral vascular disease.
We need to produce a longer follow-up since one-year mortality was not influenced by MMP3 and ACE polymorphisms.
No relevant competing interests disclosed.
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