Musculoskeletal Pain & Analgesia | Cartilage Disorders & Osteoarthritis | Pain Management: Chronic Clinical
Discordance between radiographic and clinical osteoarthritis symptoms is associated with altered pain processing
Patrick H Finan, Shahid Hussain, Uzma Haque, Virginia Coryell, Raymond Park, Lea McCauley, Sara Bounds, Phillip Quartana, Luis Buenaver, Claudia Campbell, Jennifer Haythornthwaite, Michael T Smith*
*Corresponding author: Michael T Smith
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
F1000Posters 2012, 3: 616 (poster) [English]
Poster [454.42 KB] | Recommended by F1000Prime
Presented at
31st Annual Scientific Meeting of the American Pain Society 2012,
16 - 19 May 2012, 206
Evidence suggests that radiographic measures of knee osteoarthritis (K-OA) pathology only weakly correlate with clinical pain. We sought to evaluate possible differences in pain sensitivity and psychosocial distress profiles between K-OA patients with discordant versus congruent clinical pain reports relative to radiographic severity measures.
K-OA patients with high clinical pain in the absence of moderate to severe radiographic OA symptoms display abnormalities in pain processing. The findings were not explained by clinical pain severity alone or the presence of psychosocial distress, suggesting that the discordance between clinical and radiographic OA symptoms may be driven by underlying pathophysiological processes, such as central sensitization.
These findings should be replicated in a larger representative OA sample. If replicated, the findings should spur further research on how this subgroup of OA patients is medically managed.
No relevant competing interests disclosed.
National Institutes of Health (NIH), NINDS/NINR grant T32 NS070201
National Institutes of Health (NIH), R01 AR05487
National Institutes of Health (NIH), R01 AR059410
National Institutes of Health (NIH), R01 DE019731
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